Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | set03_wtNotch_versus_normalThy |
| Phenotype | NoPhenotypeAvailable |
| Upregulated in class | na_neg |
| GeneSet | NCI_TGF-BETA RECEPTOR SIGNALING |
| Enrichment Score (ES) | -0.4785709 |
| Normalized Enrichment Score (NES) | -1.8625203 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.11446941 |
| FWER p-Value | 0.758 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IL5 | 54 | 6.551 | 0.0094 | No | ||
| 2 | CEBPB | 67 | 6.161 | 0.0203 | No | ||
| 3 | EIF4EBP1 | 123 | 5.427 | 0.0275 | No | ||
| 4 | FGR | 155 | 5.100 | 0.0354 | No | ||
| 5 | RBBP7 | 416 | 3.867 | 0.0285 | No | ||
| 6 | CDK4 | 450 | 3.776 | 0.0338 | No | ||
| 7 | MAPKAPK2 | 468 | 3.735 | 0.0399 | No | ||
| 8 | CCND1 | 475 | 3.721 | 0.0466 | No | ||
| 9 | MAP3K7IP1 | 524 | 3.584 | 0.0507 | No | ||
| 10 | EIF4E | 566 | 3.497 | 0.0550 | No | ||
| 11 | RIPK1 | 687 | 3.202 | 0.0545 | No | ||
| 12 | TCF3 | 904 | 2.852 | 0.0481 | No | ||
| 13 | CDKN1A | 1088 | 2.662 | 0.0432 | No | ||
| 14 | SAP18 | 1144 | 2.598 | 0.0450 | No | ||
| 15 | MYC | 1285 | 2.465 | 0.0421 | No | ||
| 16 | SLC3A2 | 1409 | 2.354 | 0.0398 | No | ||
| 17 | EEF2K | 1461 | 2.311 | 0.0413 | No | ||
| 18 | RUNX2 | 1507 | 2.283 | 0.0432 | No | ||
| 19 | GRB2 | 1642 | 2.197 | 0.0400 | No | ||
| 20 | DUSP10 | 1647 | 2.194 | 0.0439 | No | ||
| 21 | TP53 | 1792 | 2.107 | 0.0400 | No | ||
| 22 | DAB2 | 1839 | 2.076 | 0.0414 | No | ||
| 23 | STRAP | 2022 | 1.973 | 0.0352 | No | ||
| 24 | YWHAQ | 2088 | 1.942 | 0.0353 | No | ||
| 25 | DLX1 | 2142 | 1.913 | 0.0361 | No | ||
| 26 | LYN | 2171 | 1.899 | 0.0381 | No | ||
| 27 | NFATC2 | 2224 | 1.873 | 0.0388 | No | ||
| 28 | ATF1 | 2272 | 1.850 | 0.0397 | No | ||
| 29 | RUNX3 | 2761 | 1.626 | 0.0162 | No | ||
| 30 | TH | 2774 | 1.621 | 0.0186 | No | ||
| 31 | EGR3 | 2875 | 1.586 | 0.0161 | No | ||
| 32 | RPS6KA5 | 3014 | 1.536 | 0.0115 | No | ||
| 33 | HSPB1 | 3059 | 1.519 | 0.0119 | No | ||
| 34 | TBX21 | 3102 | 1.505 | 0.0125 | No | ||
| 35 | YWHAZ | 3177 | 1.476 | 0.0112 | No | ||
| 36 | NR3C1 | 3247 | 1.453 | 0.0102 | No | ||
| 37 | SOS1 | 3421 | 1.389 | 0.0034 | No | ||
| 38 | FOXO3 | 3546 | 1.350 | -0.0008 | No | ||
| 39 | SNTA1 | 3647 | 1.317 | -0.0038 | No | ||
| 40 | USF1 | 3957 | 1.226 | -0.0183 | No | ||
| 41 | MAP3K6 | 3960 | 1.225 | -0.0161 | No | ||
| 42 | PIAS3 | 4102 | 1.186 | -0.0216 | No | ||
| 43 | PRKCD | 4150 | 1.173 | -0.0219 | No | ||
| 44 | RBBP4 | 4202 | 1.157 | -0.0225 | No | ||
| 45 | CDC25B | 4204 | 1.157 | -0.0204 | No | ||
| 46 | BAD | 4407 | 1.108 | -0.0293 | No | ||
| 47 | RAN | 4431 | 1.102 | -0.0285 | No | ||
| 48 | TNF | 4598 | 1.062 | -0.0356 | No | ||
| 49 | E2F1 | 4642 | 1.052 | -0.0359 | No | ||
| 50 | AR | 4664 | 1.045 | -0.0351 | No | ||
| 51 | PLA2G4A | 4682 | 1.041 | -0.0341 | No | ||
| 52 | RNF128 | 4690 | 1.039 | -0.0325 | No | ||
| 53 | ZFYVE16 | 4693 | 1.039 | -0.0307 | No | ||
| 54 | PRKACA | 4799 | 1.014 | -0.0345 | No | ||
| 55 | RALA | 4847 | 1.002 | -0.0352 | No | ||
| 56 | MAP3K7 | 5000 | 0.970 | -0.0416 | No | ||
| 57 | TGIF2 | 5113 | 0.942 | -0.0459 | No | ||
| 58 | IL4 | 5143 | 0.933 | -0.0458 | No | ||
| 59 | MAPKAPK5 | 5303 | 0.891 | -0.0528 | No | ||
| 60 | PPARGC1A | 5777 | 0.779 | -0.0771 | No | ||
| 61 | MAP2K4 | 5861 | 0.762 | -0.0801 | No | ||
| 62 | MAPK13 | 6168 | 0.698 | -0.0955 | No | ||
| 63 | CAV1 | 6171 | 0.697 | -0.0943 | No | ||
| 64 | CAMK2A | 6209 | 0.688 | -0.0950 | No | ||
| 65 | DUSP8 | 6405 | 0.647 | -0.1044 | No | ||
| 66 | KPNB1 | 6534 | 0.622 | -0.1102 | No | ||
| 67 | YWHAB | 6626 | 0.604 | -0.1141 | No | ||
| 68 | XPO1 | 6628 | 0.603 | -0.1130 | No | ||
| 69 | CAMK2B | 6676 | 0.594 | -0.1144 | No | ||
| 70 | COL1A2 | 6696 | 0.591 | -0.1143 | No | ||
| 71 | AKT1 | 6886 | 0.551 | -0.1236 | No | ||
| 72 | PTGS2 | 6894 | 0.550 | -0.1229 | No | ||
| 73 | BAMBI | 7017 | 0.525 | -0.1286 | No | ||
| 74 | STMN1 | 7185 | 0.491 | -0.1368 | No | ||
| 75 | PRKCA | 7407 | 0.444 | -0.1480 | No | ||
| 76 | CASP3 | 7517 | 0.422 | -0.1531 | No | ||
| 77 | TFDP1 | 7688 | 0.390 | -0.1617 | No | ||
| 78 | SERPINE1 | 7689 | 0.390 | -0.1609 | No | ||
| 79 | IL2RA | 7719 | 0.384 | -0.1618 | No | ||
| 80 | SMAD7 | 7752 | 0.378 | -0.1628 | No | ||
| 81 | CAMK4 | 7761 | 0.376 | -0.1625 | No | ||
| 82 | GADD45G | 7848 | 0.356 | -0.1666 | No | ||
| 83 | CDKN2B | 8028 | 0.320 | -0.1757 | No | ||
| 84 | FOXG1 | 8201 | 0.282 | -0.1845 | No | ||
| 85 | ITGB5 | 8213 | 0.279 | -0.1846 | No | ||
| 86 | GSC | 8229 | 0.276 | -0.1849 | No | ||
| 87 | MAPKAPK3 | 8256 | 0.270 | -0.1858 | No | ||
| 88 | NUP153 | 8272 | 0.267 | -0.1861 | No | ||
| 89 | CTGF | 8285 | 0.264 | -0.1863 | No | ||
| 90 | BLK | 8442 | 0.237 | -0.1943 | No | ||
| 91 | PRKCZ | 8446 | 0.236 | -0.1941 | No | ||
| 92 | ATF3 | 8450 | 0.234 | -0.1938 | No | ||
| 93 | RAC1 | 8465 | 0.231 | -0.1941 | No | ||
| 94 | IFNB1 | 8602 | 0.204 | -0.2011 | No | ||
| 95 | HDAC2 | 8618 | 0.200 | -0.2016 | No | ||
| 96 | RPS6KA4 | 8727 | 0.180 | -0.2071 | No | ||
| 97 | CALM1 | 8771 | 0.170 | -0.2092 | No | ||
| 98 | HCK | 8805 | 0.162 | -0.2106 | No | ||
| 99 | NCOR1 | 8971 | 0.131 | -0.2194 | No | ||
| 100 | FKBP8 | 9068 | 0.113 | -0.2244 | No | ||
| 101 | MAP3K10 | 9073 | 0.112 | -0.2244 | No | ||
| 102 | FOXH1 | 9320 | 0.067 | -0.2377 | No | ||
| 103 | CD40LG | 9328 | 0.064 | -0.2379 | No | ||
| 104 | NKX2-5 | 9446 | 0.039 | -0.2442 | No | ||
| 105 | ARRB2 | 9665 | -0.005 | -0.2561 | No | ||
| 106 | MAX | 9716 | -0.014 | -0.2588 | No | ||
| 107 | SKIL | 9772 | -0.022 | -0.2618 | No | ||
| 108 | RBL1 | 9838 | -0.036 | -0.2652 | No | ||
| 109 | YWHAE | 9858 | -0.041 | -0.2662 | No | ||
| 110 | YES1 | 9865 | -0.042 | -0.2664 | No | ||
| 111 | YWHAG | 10062 | -0.083 | -0.2770 | No | ||
| 112 | KPNA2 | 10102 | -0.091 | -0.2789 | No | ||
| 113 | PAK3 | 10206 | -0.112 | -0.2843 | No | ||
| 114 | TAOK2 | 10248 | -0.120 | -0.2863 | No | ||
| 115 | PARD6A | 10366 | -0.141 | -0.2924 | No | ||
| 116 | MAP2K3 | 10511 | -0.169 | -0.3000 | No | ||
| 117 | EGR4 | 10529 | -0.173 | -0.3006 | No | ||
| 118 | MEF2C | 11230 | -0.324 | -0.3381 | No | ||
| 119 | CITED1 | 11335 | -0.348 | -0.3431 | No | ||
| 120 | SRC | 11366 | -0.352 | -0.3441 | No | ||
| 121 | MAP3K4 | 11463 | -0.376 | -0.3486 | No | ||
| 122 | VDR | 11551 | -0.394 | -0.3526 | No | ||
| 123 | CTDSPL | 11650 | -0.416 | -0.3571 | No | ||
| 124 | MAP3K7IP2 | 11673 | -0.421 | -0.3575 | No | ||
| 125 | MAPK3 | 11722 | -0.435 | -0.3593 | No | ||
| 126 | FOS | 11810 | -0.455 | -0.3632 | No | ||
| 127 | HNF4A | 11872 | -0.467 | -0.3657 | No | ||
| 128 | PRKCE | 12144 | -0.521 | -0.3794 | No | ||
| 129 | ZFYVE9 | 12392 | -0.577 | -0.3918 | No | ||
| 130 | PRKG1 | 12437 | -0.589 | -0.3931 | No | ||
| 131 | FOSL1 | 12479 | -0.600 | -0.3942 | No | ||
| 132 | CSNK2A1 | 12552 | -0.617 | -0.3970 | No | ||
| 133 | TSC2 | 12633 | -0.636 | -0.4001 | No | ||
| 134 | CSF2 | 12718 | -0.657 | -0.4035 | No | ||
| 135 | NR4A1 | 12782 | -0.668 | -0.4056 | No | ||
| 136 | DACT2 | 12912 | -0.699 | -0.4114 | No | ||
| 137 | IL2 | 13006 | -0.720 | -0.4151 | No | ||
| 138 | ZBTB17 | 13177 | -0.769 | -0.4229 | No | ||
| 139 | CREBBP | 13192 | -0.773 | -0.4222 | No | ||
| 140 | IL3 | 13241 | -0.787 | -0.4233 | No | ||
| 141 | HDAC1 | 13265 | -0.791 | -0.4231 | No | ||
| 142 | MITF | 13419 | -0.828 | -0.4299 | No | ||
| 143 | CBFB | 13422 | -0.828 | -0.4284 | No | ||
| 144 | CTBP1 | 13564 | -0.864 | -0.4345 | No | ||
| 145 | MYOD1 | 13586 | -0.870 | -0.4340 | No | ||
| 146 | PAK2 | 13592 | -0.871 | -0.4326 | No | ||
| 147 | HSPA8 | 13628 | -0.880 | -0.4329 | No | ||
| 148 | E2F5 | 13649 | -0.885 | -0.4323 | No | ||
| 149 | OCLN | 13943 | -0.971 | -0.4464 | No | ||
| 150 | DYNLRB1 | 13995 | -0.985 | -0.4474 | No | ||
| 151 | ELK4 | 13997 | -0.985 | -0.4456 | No | ||
| 152 | CALM2 | 14059 | -1.001 | -0.4470 | No | ||
| 153 | JUN | 14245 | -1.057 | -0.4551 | No | ||
| 154 | CBLB | 14325 | -1.083 | -0.4574 | No | ||
| 155 | PTPRK | 14407 | -1.106 | -0.4597 | No | ||
| 156 | TGFBR1 | 14475 | -1.126 | -0.4612 | No | ||
| 157 | RALB | 14527 | -1.142 | -0.4619 | No | ||
| 158 | ESR1 | 14537 | -1.146 | -0.4602 | No | ||
| 159 | SIN3A | 14571 | -1.154 | -0.4598 | No | ||
| 160 | RPS6KB1 | 14689 | -1.195 | -0.4640 | No | ||
| 161 | PAK1 | 14871 | -1.265 | -0.4714 | No | ||
| 162 | MEF2D | 15003 | -1.317 | -0.4761 | Yes | ||
| 163 | PTPN1 | 15017 | -1.323 | -0.4743 | Yes | ||
| 164 | MAPK8 | 15028 | -1.330 | -0.4724 | Yes | ||
| 165 | SAP30 | 15127 | -1.369 | -0.4751 | Yes | ||
| 166 | GATA3 | 15140 | -1.374 | -0.4732 | Yes | ||
| 167 | IFNG | 15149 | -1.377 | -0.4710 | Yes | ||
| 168 | SKI | 15180 | -1.394 | -0.4701 | Yes | ||
| 169 | UBE2I | 15186 | -1.396 | -0.4677 | Yes | ||
| 170 | RAB5A | 15211 | -1.406 | -0.4664 | Yes | ||
| 171 | SLC9A1 | 15311 | -1.449 | -0.4690 | Yes | ||
| 172 | MAPK14 | 15392 | -1.490 | -0.4706 | Yes | ||
| 173 | MAPK12 | 15410 | -1.504 | -0.4687 | Yes | ||
| 174 | ETV1 | 15424 | -1.513 | -0.4666 | Yes | ||
| 175 | ATM | 15455 | -1.529 | -0.4653 | Yes | ||
| 176 | DDIT3 | 15582 | -1.600 | -0.4692 | Yes | ||
| 177 | CTDSP1 | 15610 | -1.614 | -0.4676 | Yes | ||
| 178 | SP1 | 15765 | -1.699 | -0.4728 | Yes | ||
| 179 | PPP1CA | 15787 | -1.712 | -0.4707 | Yes | ||
| 180 | IL10 | 15830 | -1.735 | -0.4698 | Yes | ||
| 181 | POU2F1 | 15845 | -1.743 | -0.4672 | Yes | ||
| 182 | MAP3K5 | 15909 | -1.779 | -0.4673 | Yes | ||
| 183 | RAF1 | 15947 | -1.805 | -0.4660 | Yes | ||
| 184 | MAPK1 | 15982 | -1.834 | -0.4644 | Yes | ||
| 185 | MEF2A | 16038 | -1.869 | -0.4638 | Yes | ||
| 186 | IRF4 | 16084 | -1.898 | -0.4627 | Yes | ||
| 187 | CSNK1A1 | 16088 | -1.901 | -0.4593 | Yes | ||
| 188 | MAP3K1 | 16099 | -1.908 | -0.4563 | Yes | ||
| 189 | GADD45B | 16108 | -1.917 | -0.4531 | Yes | ||
| 190 | SMAD2 | 16115 | -1.921 | -0.4498 | Yes | ||
| 191 | YAP1 | 16273 | -2.040 | -0.4545 | Yes | ||
| 192 | SHC1 | 16319 | -2.078 | -0.4531 | Yes | ||
| 193 | PPM1A | 16327 | -2.082 | -0.4496 | Yes | ||
| 194 | PPARG | 16361 | -2.107 | -0.4474 | Yes | ||
| 195 | SFN | 16365 | -2.109 | -0.4436 | Yes | ||
| 196 | NCOA2 | 16407 | -2.145 | -0.4418 | Yes | ||
| 197 | PRKCH | 16424 | -2.159 | -0.4386 | Yes | ||
| 198 | RUNX1 | 16466 | -2.190 | -0.4367 | Yes | ||
| 199 | PPP2CA | 16469 | -2.192 | -0.4327 | Yes | ||
| 200 | MKNK1 | 16480 | -2.203 | -0.4291 | Yes | ||
| 201 | ATF2 | 16651 | -2.349 | -0.4340 | Yes | ||
| 202 | TRAF6 | 16659 | -2.353 | -0.4299 | Yes | ||
| 203 | CTLA4 | 16721 | -2.425 | -0.4287 | Yes | ||
| 204 | PKN1 | 16817 | -2.518 | -0.4291 | Yes | ||
| 205 | LCK | 16851 | -2.559 | -0.4261 | Yes | ||
| 206 | SNIP1 | 16857 | -2.564 | -0.4216 | Yes | ||
| 207 | PIAS4 | 16864 | -2.571 | -0.4171 | Yes | ||
| 208 | DAXX | 17045 | -2.781 | -0.4216 | Yes | ||
| 209 | TRAF2 | 17084 | -2.837 | -0.4184 | Yes | ||
| 210 | CDK2 | 17094 | -2.849 | -0.4135 | Yes | ||
| 211 | MAPK9 | 17129 | -2.896 | -0.4099 | Yes | ||
| 212 | GSK3B | 17139 | -2.906 | -0.4049 | Yes | ||
| 213 | RNF111 | 17153 | -2.925 | -0.4001 | Yes | ||
| 214 | PPP2CB | 17169 | -2.944 | -0.3954 | Yes | ||
| 215 | SMAD3 | 17176 | -2.959 | -0.3902 | Yes | ||
| 216 | CREB1 | 17191 | -2.984 | -0.3854 | Yes | ||
| 217 | CALM3 | 17223 | -3.039 | -0.3813 | Yes | ||
| 218 | SIN3B | 17301 | -3.148 | -0.3796 | Yes | ||
| 219 | JUNB | 17330 | -3.198 | -0.3751 | Yes | ||
| 220 | SMURF2 | 17371 | -3.269 | -0.3712 | Yes | ||
| 221 | PRKCQ | 17373 | -3.270 | -0.3651 | Yes | ||
| 222 | YWHAH | 17395 | -3.317 | -0.3600 | Yes | ||
| 223 | NCOA1 | 17413 | -3.345 | -0.3546 | Yes | ||
| 224 | FKBP1A | 17483 | -3.475 | -0.3518 | Yes | ||
| 225 | ITCH | 17608 | -3.701 | -0.3516 | Yes | ||
| 226 | MAP3K8 | 17644 | -3.789 | -0.3464 | Yes | ||
| 227 | PML | 17686 | -3.872 | -0.3414 | Yes | ||
| 228 | FASLG | 17717 | -3.934 | -0.3356 | Yes | ||
| 229 | DUSP1 | 17723 | -3.944 | -0.3285 | Yes | ||
| 230 | SRF | 17731 | -3.958 | -0.3214 | Yes | ||
| 231 | MAP3K12 | 17778 | -4.065 | -0.3163 | Yes | ||
| 232 | SMAD4 | 17839 | -4.206 | -0.3116 | Yes | ||
| 233 | FYN | 17854 | -4.233 | -0.3044 | Yes | ||
| 234 | MAPK11 | 17912 | -4.438 | -0.2992 | Yes | ||
| 235 | MAP2K6 | 17919 | -4.460 | -0.2911 | Yes | ||
| 236 | LSP1 | 17923 | -4.470 | -0.2829 | Yes | ||
| 237 | NFATC1 | 18056 | -4.862 | -0.2810 | Yes | ||
| 238 | MAP3K3 | 18061 | -4.882 | -0.2720 | Yes | ||
| 239 | PIM1 | 18097 | -5.045 | -0.2644 | Yes | ||
| 240 | NFATC3 | 18098 | -5.049 | -0.2549 | Yes | ||
| 241 | RHOA | 18172 | -5.441 | -0.2487 | Yes | ||
| 242 | FOXP3 | 18238 | -5.724 | -0.2415 | Yes | ||
| 243 | PDPK1 | 18265 | -5.919 | -0.2317 | Yes | ||
| 244 | NEDD4L | 18277 | -5.997 | -0.2211 | Yes | ||
| 245 | TGFBR2 | 18307 | -6.182 | -0.2110 | Yes | ||
| 246 | CCM2 | 18325 | -6.280 | -0.2002 | Yes | ||
| 247 | AXIN1 | 18349 | -6.535 | -0.1891 | Yes | ||
| 248 | TGFBR3 | 18360 | -6.633 | -0.1772 | Yes | ||
| 249 | EGR1 | 18429 | -7.374 | -0.1670 | Yes | ||
| 250 | GDI1 | 18447 | -7.530 | -0.1538 | Yes | ||
| 251 | HBP1 | 18469 | -7.955 | -0.1400 | Yes | ||
| 252 | CTDSP2 | 18498 | -8.415 | -0.1257 | Yes | ||
| 253 | GADD45A | 18507 | -8.591 | -0.1100 | Yes | ||
| 254 | DUSP16 | 18514 | -8.989 | -0.0934 | Yes | ||
| 255 | BCL2 | 18530 | -9.542 | -0.0763 | Yes | ||
| 256 | DGKA | 18533 | -9.632 | -0.0583 | Yes | ||
| 257 | LAMC1 | 18557 | -10.686 | -0.0395 | Yes | ||
| 258 | EGR2 | 18610 | -22.681 | 0.0003 | Yes |
